Endocrine Abstracts

Our previous work has shown that the intake of a high fat high carbohydrate (HFHC) meal results in an increase in endotoxin (LPS) and LPS binding protein (LBP) concentrations concomitant with an increase in the expression of TLR-4, the receptor for LPS, and CD-14, which facilitates the binding of LPS to its receptor. In addition, there is an increase in ROS generation, NFkB binding and the expression of TNF-α and IL-1β. Our work has also demonstrated that an equicalo...